The few superheroes remaining after Thanos destroys half the universe with the Infinity Gauntlet stand with the cosmic forces of space and time, love and hate, and order and chaos in an effort to save what is left of the Earth, but it will take a nearly-forgotten hero from another era to strip Thanos of power.

"Mutants are all around us. Some are good, others unspeakably evil. But they are all gifted, gifted with a unique X-Factor in their genetic makeup that makes them living weapons, manifesting itself through wondrous powers. And, even within this special community, there is a group that has distinguished itself the uncanny X-Men who have honed their awesome abilities and pledged them in the service of mankind. Gathered by the mutant telepath, Charles...